Publications while at Wesleyan

  • Rafalowski, A.#, ∈; Hassan, B. A.#, ∈; Lou, K.*; Nguyen, M. C.*; Taylor, E. A., “How Single Amino Acid Substitutions Can Disrupt a Protein Hetero-Dimer Interface: Computational and Experimental Studies of the LigAB Dioxygenase from Sphingobium sp. strain SYK-6,” International Journal of Molecular Sciences, 2023, 24(7), 6319. (∈Joint first authors; DOI: 10.3390/ijms24076319)
  • Hassan, B. A.#; Liu, Z. A.; Milicaj, J.#,∈; Kim, M. S.; Tyson, M.; Sham, Y. Y.; Taylor, E. A. “Characterization of Escherichia coli Heptosyltransferase II, a Lipopolysaccharide Biosynthetic Enzyme of the GT-B Structural Class,” Biochemistry, 2022, 15, 1572–1584. (DOI: 10.1021/acs.biochem.2c00329)
  • Milicaj, J.#, ∈; Hassan, B. A.#, ∈; Cote, J. M.#; Ramirez-Mondragon, C. A.#; Jaunbocus, N.; Rafalowski, A.#; Patel, K. R.; Castro, C. D.*; Muthayala, R.; Sham, Y. Y.∇; Taylor, E. A.∇, “Discovery of first-in-class nanomolar inhibitors of heptosyltransferase I reveals a new aminoglycoside target and potential alternative mechanism of action,” Scientific Reports, 2022, 12, 7302. (∈Joint first authors; ∇Joint Corresponding Authors; DOI: 10.1038/s41598-022-10776-x)
  • Milicaj, J.#, ∈; Dodda, V. R. ∈; Patel, K. R.; Aragon, I. R.; O’Connell, T.; Muthyala, R. ∇; Taylor, E. A. ∇; Sham, Y. Y. ∇, “Facile and Adaptable Synthesis of a Prazosin Analogue Library: Bringing Medicinal Chemistry into the Undergraduate Curriculum,” Journal of Chemistry Education, 2022, 99, 1428-1434. (∈Joint first authors; ∇Joint Corresponding Authors; DOI: 10.1021/acs.jchemed.1c00822)
  • Hassan, B. A.#; Milicaj, J.#; Ramirez-Mondragon, C. A.#; Sham, Y. Y.∇; Taylor, E. A. ∇ “Ligand Induced Conformational and Dynamical Changes in a GT-B Glycosyltransferase: Molecular Dynamic Simulations of Heptosyltransferase I Apo, Binary and Ternary Complexes,” Journal of Chemical Information and Modeling, 2022, 62, 324-339. (∇Joint Corresponding Authors; DOI: 10.1021/acs.jcim.1c00868).
  • Shukla, N.; Bembenek, B.; Taylor, E. A.; Othon, C.M., “Conformational Consequences for Compatible Osmolytes on Thermal Denaturation,” Life, 2021, 11, 1394. (DOI: 10.3390/life11121394; This article belongs to the Special Issue How Cosolvents and Cosolutes Affect Biomolecules Stability and Activity)
  • Milicaj, J.#; Castro, C. D.; Jaunbocus, N.; Taylor, E. A. “Extraction of ADP-heptose and Kdo2-Lipid A from E. coli Deficient in the Heptosyltransferase I Gene,” Applied Sciences, 2021, 11, 8314. (DOI: 10.3390/app11188314; This article belongs to the Special Issue Polysaccharides: From Extraction to Applications)
  • Ramirez-Mondragon, C. A.#; Nguyen, M. E.; Milicaj, J.#; Hassan, B. A.#; Tucci, F. J.; Muthayala, R.; Taylor, E. A.; Sham, Y. Y., “Conserved Conformational Hierarchy Across Functionally Divergent Glycosyltransferases of the GT-B Structural Superfamily as Determined from Microsecond Molecular Dynamics,” International Journal of Molecular Sciences, 2021, 22(9), 4619. (DOI: 10.3390/ijms22094619)
  • Li, T.; Tikad, A.; Fu, H.; Milicaj, J.#; Castro, C. D.; Lacritick, M.; Pan, W.-D.; Taylor, E. A.; Vincent, S. P., “A General Strategy to Synthesize ADP-7-azido-heptose and ADP-azido-mannoses and their Heptosyltransferase Binding Properties,” Organic Letters, 2021, 23, 1638–1642. (DOI: 10.1021/acs.orglett.1c00048)
  • Uchendu, S. N.; Rafalowski, A.#; Schick, D. L.; Cohn, E. F.; Hassan, B. A.#; Taylor, E. A., “Identifying Metabolic Pathway Intermediates that Modulate Enzyme Activity: A Kinetic Analysis of the DesB Dioxygenase from Sphingobium sp. strain SYK-6,” Process Biochemistry, 2021, 102, 408-416. (DOI: 10.1016/j.procbio.2021.01.019)
  • Cote, J. M.#; Hecht, C. J. S.; Patel, K.; Ramirez-Mondragon, C. A.#; Sham,Y. Y.; and Taylor E. A., “Opposites Attract: Positively Charged Residues Facilitating Substrate Induced Conformational Changes of Heptosyltransferase I,” Biochemistry, 2020, 59, 3135-3147. (DOI: 10.1021/acs.biochem.9b01005)
  • Henry, R. A.; Kuo, Y.-M.; Siegel, Z. S.; Yen, T.; Rhodes, J.; Taylor, E. A.; Andrews, A. J., “Discordant Effects of Putative Lysine Acetyltransferase Inhibitors in Biochemical and Living Systems,” Cells, 2019, 8(9), 1022 (16 pages). (DOI: 10.3390/cells8091022; This article belongs to the Special Issue Evolution of Epigenetic Mechanisms and Signatures)
  • Taylor, E. A. “Lignin Enzymology – Recent Efforts to Understand Lignin Monomer Catabolism.” In Comprehensive Natural Products III: Chemistry and Biology; Begley, T. P., Liu, H.-W., Eds.; Elsevier: 2020; Vol. 4, pages 373-398. (Book ISBN: 9780081026908)
  • Shukla, N.; Goeks, J.; Taylor, E.A.; Othon, C., “Hydration Dynamics in Solutions of Cyclic Polyhydroxyl Osmolytes,” The Journal of Physical Chemistry, Part B, 2019, 123:40, 8472-8479. (DOI: 10.1021/acs.jpcb.9b06861)
  • Burroughs, A. M.; Glasner, M.; Barry, K. P.#; Taylor, E. A.; Aravind, L., “Oxidative Opening of the Aromatic Ring: Tracing the Natural History of a Large Superfamily of Dioxygenase Domains and their Relatives,” Journal of Biological Chemistry, 2019, 294, 10211-10235. (DOI: 10.1074/jbc.RA119.007595)
  • Uchendu, S. N.; Rafalowski, A.#; Cohn, E. F.; Davoren, L. W.; Taylor, E. A., “Anaerobic Protein Purification and Kinetic Analysis via Oxygen Electrode for Studying Dioxygenase Activity and Inhibition of DesB,” Journal of Visualized Experiments, 2018, 140, e58307. (DOI: 10.3791/58307)
  • Nkosana, N. K.; Czyzyk, D. J.#; Siegel, Z. S.; Cote, J. M. #; Taylor, E. A., “Synthesis, Kinetics and Inhibition of Escherichia coli Heptosyltransferase I by Monosaccharide Analogues of LipidA,” Bioorganic and Medicinal Chemistry Letters, 2018, 28(4), 594-600. (DOI: 10.1016/j.bmcl.2018.01.040)
  • Shukla, N.; Pomarico, E.; Hecht, C. J. S.; Taylor, E. A.; Chergui, M.; Othon, C.M., “Hydrophobic Interactions of Sucralose with Protein Structures,” Archives of Biochemistry and Biophysics, 2018, 639, 38-43. (DOI: 10.1016/j.abb.2017.12.013)
  • Cote, J. M.#; Taylor, E. A., “The Glycosyltransferases of LPS Core: A Review of Four Heptosyltransferase Enzymes in Context,” International Journal of Molecular Sciences, 2017, 18(11), 2256. (DOI: 10.3390/ijms18112256; This article belongs to the Special Issue Lipopolysaccharides (LPSs))
  • Chandrashekar, S.; Shellikeri, A.; Taylor, E. A.; Taylor, D.; Chandrahekar, S., “Visualizing Electromagnetic Fields in Metals by MRI,” AIP Advances, 2017, 7, 025310. (DOI: 10.1063/1.4977700)
  • Cote, J. M.#; Ramirez-Mondragon, C. A.; Siegel, Z. Z.; Czyzyk, D. J. #; Gao, J.; Sham, Y. S.; Mukerji, I.; Taylor, E. A., “The Stories Tryptophans Tell: Exploring Protein Dynamics of Heptosyltransferase I from Escherichia coli,” Biochemistry, 2017, 56, 886-895. (DOI: 10.1021/acs.biochem.6b00850; PMCID: PMC5546316)
  • Christian, T.; Sakaguchi1, R.; Perlinska, A. P.; Lahoud, G.; Ito, T.; Taylor, E. A.; Yokoyama, S.; Sulkowska, I.; Hou, Y.-M., “Methyl Transfer by Substrate Signaling from a Knotted Protein Fold,” Nature Structural and Molecular Biology, 2016, 23, 941-948. (DOI:10.1038/nsmb.3282)
  • Barry, K. P.#; Cohn, E. F.; Ngu, A.; Taylor, E. A., “Improving Alternate Lignin Catabolite Utilization of LigAB from Sphingobium strain SYK-6 through Site Directed Mutagenesis,” Process Biochemistry, 2015, 50, 1634-1639. (DOI: 10.1016/j.procbio.2015.05.024)
  • Mudapaka, J.#; Taylor, E. A., “Purification and Biochemical Characterization of the HeptosyltransferaseIII from Escherichia coli,” FEBS Letters, 2015, 589, 1423-1429. (DOI: 10.1016/j.febslet.2015.04.051
  • Chen, L.; Shukla, N.; Cho, I.; Cohn, E. F.; Taylor, E. A.; Othon, C. M., “Sucralose Destabilization of Protein Structure,” Journal of Physical Chemistry Letters, 2015, 6, 1441-1446. (DOI:  10.1021/acs.jpclett.5b00442)
  • Barry, K. P.#; Ngu, A.; Cohn, E. F.; Cote, J. M.#; Gerbino, J. P.#; Taylor, E. A., “Exploring allosteric activation of LigAB from Sphingobium sp. strain SYK-6 through kinetics, mutagenesis and computational studies,” Archives of Biochemistry and Biophysics, 2015, 567, 35-45. (DOI: 10.1016/j.abb.2014.12.019)
  • Barry, K. P.#; Taylor, E. A., “Characterizing the Promiscuity of LigAB, a Lignin Catabolite Degrading Extradiol Dioxygenase from Sphingomonas paucimobilis SYK-6,” Biochemistry, 2013, 52, 6724-6736. (DOI: 10.1021/bi400665t; PMCID: PMC3926093)
  • Czyzyk, D. J.#; Sawant, S.; Ramirez-Mondragon, C. A. #; Hingorani, M. M.; Taylor, E. A., “Escherichia coli Heptosyltransferase I: Investigation of Protein Dynamics of a GT-B Structural Enzyme,” Biochemistry, 2013, 52, 5158-5160. (DOI: 10.1021/bi400807r; PMCID: PMC3867311)
  • Czyzyk, D. J.#; Liu, C.; Taylor, E. A., “Lipopolysaccharide Biosynthesis without the Lipids: Substrate recognition for Escherichia coli HeptosyltransferaseI,”, Biochemistry, 2011, 50, 10570-10572. (DOI: 10.1021/bi201581b)

Undergraduate co-authors underlined; Graduate student co-authors indicated with #

For a more complete list click here.